The eukaryotic translation initiation factor eIF4E wears a “cap” for many occasions

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The eukaryotic translation initiation factor eIF4E wears a “cap” for many occasions

The eukaryotic translation initiation factor eIF4E plays important roles in controlling the composition of the proteome. Indeed, dysregulation of eIF4E is associated with poor prognosis cancers. The traditional view has been that eIF4E acts solely in translation. However, over the last ∼25 years, eIF4E was found in the nucleus where it acts in mRNA export and in the last ∼10 years, eIF4E was fo...

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Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

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ژورنال

عنوان ژورنال: Translation

سال: 2016

ISSN: 2169-0731

DOI: 10.1080/21690731.2016.1220899